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. 2019 Mar 2;169(2):485–498. doi: 10.1093/toxsci/kfz055

Figure 2.

Figure 2.

Porphyrin/bilirubin export but not production is regulated by Nrf2. Heme biosynthesis pathway and export mechanisms were investigated by qRT-PCR as depicted in the schematic overview. Gene expression of (A) protoporphyrin IX (PpIX)-producing protoporphyrinogen oxidases (Ppox) and (B) PpIX-facilitating and heme-synthetizing ferrochelatase (Fech) are shown. Gene expression analyses of the mitochondrial efflux transporters (C) translocator protein (Tspo) and (D) feline leukemia virus subgroup C cellular receptor 1 (Flvcr1) are depicted. The hepatic efflux transporters ATP-binding cassette subfamily G/C member 2 (Abcg2 and Abcc2) toward bile ducts are shown in (E and F). Results for the hepatic efflux transporters toward sinusoidal blood flow (Abcc3 and Abcc4) are shown in (G and H). n = 6; data = mean + SEM; *p < .05, **p < .01, and ***p < .001 versus control diet; #p < .05, ##p < .01, and ###p < .001 as indicated.