Table 4.
Pharmacokinetic Parameters for Oximes 15, 20, and 55 in Male Sprague Dawley Rats After Single Intramuscular (IM) Dose, 50 mg/kg
| Oxime | T max (h) | C max (ng/ml) | t 1/2(h) | AUClast (h·ng/ml) | AUCinf (h·ng/ml) | MRTlast (h) | MRTinf (h) | |
|---|---|---|---|---|---|---|---|---|
| 15a | Rat 11a | 0.500 | 2230 | 2.79 | 8874 | 9289 | 3.55 | 3.56 |
| Rat 12a | 0.500 | 3620 | 2.23 | 9268 | 9462 | 2.84 | 2.84 | |
| 20 | Mean | 0.083 | 2547 | 5.20 | 6689 | 7006 | 6.50 | 6.39 |
| SD | 0.000 | 640 | 0.59 | 945 | 1094 | 1.11 | 1.11 | |
| 55 | Mean | 0.083 | 1227 | 13.8 | 5656 | 7671 | 18.2 | 18.7 |
| SD | 0.000 | 654 | 0.31 | 1015 | 1344 | 0.13 | 0.41 |
a
There were 2 replications for Oxime 15, and 3 replications for Oximes 20 and 55. For Oxime 15, 1 animal was an outlier therefore, the data from that animal were not used in further calculations. Therefore the 2 individual values for this group are shown to illustrate that there was little individual variation in the PK parameters between the 2 rats.