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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2018 May 22;121:1–12. doi: 10.1016/j.yjmcc.2018.05.013

Figure 4. KDM4D binding and H3K9me3 status, but not accessibility, are altered in gene promoters in BiTg ACMs.

Figure 4

(A) Genome browser views of DnaseI-hypersensitivity sequencing at promoter regions (+/− 500bp from transcription start site) of stem cell (silenced), housekeeping (active), and cell cycle genes. (B) KDM4D (Myc-tag) ChIP-PCR in adult ventricle samples analysis of indicated gene promoters. (C) H3K9me3 ChIP-PCR in isolated ACMs. Sample Number: (B–C) Control=3, BiTg=3. Statistics: (B–C) Two-tailed T-test, control vs. BiTg, * P<0.05.