Table 1. Normal cardiac function and morphology in BiTg mice at 7 months.

	NonTg	tet	tTA	BiTg
HR (BPM)	450 ± 9	452 ± 11	441 ± 11	422 ± 10
EF (%)	74.1 ± 2.3	74 ± 4.4	79.2 ± 3.1	73.8 ± 4.3
FS (%)	42.1 ± 2.3	43 ± 3.8	47.6 ± 3.2	43 ± 3.8
CO (mL/min)	15.1 ± 2	19.8 ± 1	16.4 ± 1.1	18.8 ± 1.6
LVEDD(mm)	3.33 ± 0.13	3.73 ± 0.02	3.38 ± 0.09	3.74 ± 0.1

Echocardiography results in 7 month old mice. HR: Heart Rate, EF: Ejection Fraction, CO: Cardiac Output, LVEDD: Left Ventricular End-Diastolic Dimension. Mean and SEM values are shown. Sample Number: N 5 for each genotype. Statistics: One-way ANOVA/Tukey’s test,

^*P<0.05 vs NonTg,

^†P<0.05 vs tet,

^‡P<0.05 vs tTA.