Table 3.

Pharmacokinetic parameters for oxycodone after administration of crushed intranasal oxycodone ARIR, crushed intranasal IR oxycodone, or intact oral oxycodone ARIR (N = 31)

	Least Squares Means*,†
Parameter	Intact Oral Oxycodone ARIR	Crushed Intranasal Oxycodone ARIR	Crushed Intranasal IR Oxycodone
Cmax, ng/mL	56.97	40.04	55.56
Tmax, h	1.3	2.3	1.7
AUC0-t, ng • h/mL	265.38	309.21	330.77
AUC0-∞, ng • h/mL	271.98	318.82	337.91
ke, h−1	0.22	0.18	0.21
t1/2, h	3.29	3.97	3.46
AUC0–0.5 h, ng • h/mL	1.34	3.69	9.70
AUC0–1, ng • h/mL	15.57	15.04	29.84
AUC0–2 h, ng • h/mL	62.95	47.79	75.30
AUC0–8 h, ng • h/mL	211.21	212.43	254.11
AUC0–12 h, ng • h/mL	243.39	261.31	296.30
AUC0–24 h, ng • h/mL	268.13	310.85	332.94

AUC_{0–0.5, 0–1, 0–2, 0–8, 0–12, 0–24} = area under the plasma concentration-time curve from 0 h to 0.5 h, 1 h, 2 h, 8 h, 12 h, and 24 h; AUC_0-t = area under the plasma concentration-time curve from 0 h to the last measurable concentration above the lower limit of quantification; AUC_0-∞ = area under the plasma concentration-time curve from 0 h to infinity; C_max = maximum observed plasma concentration; IR = immediate release; k_e = elimination rate constant; T_max = time associated with C_max; t_1/2 = half-life.

^*Values for k_e and t_1/2 are untransformed.

^†Values for T_max are the untransformed median.