Table 2.
Frequency of IL-17F [rs763780; A7488G] and IL-17A (rs2275913; G197A) genotypes in patients and controls
| Gene | Group | Odd ratio | 95% confidence interval | P-value | |
|---|---|---|---|---|---|
| Controls (n = 100) | Patients (n = 100) | ||||
| N (%) | N (%) | ||||
| IL-17F [rs763780; A7488G] | |||||
| Wild type (AA) | 57 (57%) | 71 (71%) | Reference | ||
| Heterotype (AG) | 24 (24%) | 21 (21%) | 0.702 | 0.335-1.389 | 0.309 |
| Homotype (GG) | 19 (19%) | 8 (8%) | 0.338 | 0.138-0.829 | 0.015 |
| Mutant allele (G) | 62 (31%) | 37 (18.5%) | 0.505 | 0.317-0.805 | 0.004 |
| polymorphic genotype (AG/GG) | 43 (43) | 29 (29) | 0.541 | 0.301-0.973 | 0.039 |
| IL-17A (rs2275913; G197A) | |||||
| Wild type (GG) | 30 (30) | 31 (31) | Reference | ||
| Heterotype (GA) | 10 (10) | 23 (23) | 2.226 | 0.908-5.454 | 0.077 |
| Homotype (AA) | 60 (60) | 46 (46) | 0.742 | 0.394-1.396 | 0.354 |
| Mutant allele (A) | 130 (65%) | 115 (57.5) | 0.729 | 0.486-1.091 | 0.124 |
| Polymorphic genotype (GA/AA) | 70 (70) | 69 (69) | 0.954 | 0.522-1.742 | 0.898 |