Table 4.

Blood pressure and heart rate adverse effects for studies with p values, percentage change from baseline

Paper	Regimen	mBP (mm Hg) ±SD	mDBP (mm Hg) ±SD	mSBP (mm Hg) ±SD	mHR (beats/min)±SD
Bonthala (2000)8	P 1%, C 0.2% (2 d)	↓ 11.5±5.8%*	–	–	↑ 0.6±1.2%*
Bolt (1992)7	P 2.5% (1d), T 0.5% (2 d)	↓ 4%	–	–	↓ 1%
	C 0.5% (1d), T 0.5% (2 d)	↑ 5.1%*	–	–	↑ 3.7%†
Elibol (1997)17	C 1% (2 d)	↑ 16.2%±2.2%*†	–	–	‡
	C 1% (2 microd)	↓ 1%±2.3%*†	–	–	‡
	P 10% (2 d)	↑ 8%±0.2%*†	–	–	‡
	P 10% (2 microd)	0±1.9%*	–	–	‡
	T 0.5% (2 d)	↑ 17.5%±0.2%*†	–	–	‡
	T 0.5% (2 microd)	↓ 1.4 ± 0.3%*	–	–	‡
Isenberg (1984 March)40	C 0.5% (2 d)	↓10%±12%†	–	–	↑ 7.5%±18%
	C 0.5%, T 0.5% (2 d)	↓ 10%±12%†	–	–	↑ 7.5%±18%
	P 1%, C 0.2% (2 d)	↓ 5.8%±14%†	–	–	↓ 1.7%±11%
Isenberg (1984 July)18	C 0.5%	↓ 13.2%			↓ 3.3%
	P 1%, C 0.2%	↓ 3.8%			↓ 4.3%
	P 2.5%, T 0.5%	↑ 19.6%			↓ 5.2%
Jiang (2016)10	P 0.5%, T 0.5% (3 d)	–	↑ 8.5*†	↑ 5.4%*§	–
Khoo (2000)16	P 1%, C 0.2% (3 d)	↑ 3.7%	−1%	↑ 0.8%	↓ 4.5%
	P 2.5%, T 0.5% (3 d)	↓ 0.4%	↓ 0.3%	↓ 1.2%	↓ 6.6%
Laws (1996)11	P 2.5% (2d), C 0.5% (4 d)	–	↑ 4.8%*	↑ 5%*	↓ 1.3%*
Lees (1981)12	P 2.5%, T 0.5% (1 d)	↑ 19.4%†	↑ 19.1%†	↑ 17.1%†	0%
Merritt (1981)45	P 2.5%, T 1% (3 d)	–	–	0%	–
	P 2.5%, T 0.5%, C 0.5% (3 d)	–	–	0%	–
Phamonvaechavan (2012)23	P 2.5%, T 0.75% (2 d)	–	0%	0%	↓ 3.2%
Sindel (1986)19	P 2.5%, T 1% (2 d)	↓ 17.1%±10.4%†	–	–	–
	P 2.5%, T 0.5%, C 0.5% (2 d)	↑ 22.8%±17.4%†	–	–	↑ 10.0%±10.6%†
	P 1%, T 1% (2 d)	↑ 7.7%±9.3%†	–	–	–

*Data approximated from graph or was converted to percentage.

†P<0.05 to 0.01.

‡Data not presented.

§P=0.08.

C, cyclopentolate;P, phenylephrine;T, tropicamide;d, standard drop;mDBP, mean diastolic blood pressure;mHR, mean heart rate;mSDP, mean systolic blood pressure;microd, microdrop.