Table 1.

Baseline characteristics of both groups showing a balanced sample without significant differences between the groups

Baseline characteristics	Group with hypotonic solution n=151	Group with isotonic solution n=143	P value
Age in months*	21, 3–109	18, 2–110	0.13†
Age in months*  <12  12–24  >24	21, 3–109 56 53 45	18, 2–110 67 40 38	0.13†
Sex  Male	73	59	0.22‡
Time at study enrolment*	6±3.2	5±2.6	0.43†
Serum sodium concentrations on admission ​​(mEq/L)	142 (141–145)	143 (139–146)	0.75†
Potassium values ​​(mEq/L)	4 (3.4–4.4)	3.9 (3.5–4.8)	0.71†
Glucose values ​​in blood (mg/dL)	121 (109–171)	134 (110–168)	0.69†
Blood pH on admission	7.41 (7.35–7.45)	7.402 (7.39–7.51)	0.67†
Total volume infused by weight (mL/kg/day)	69 (45.2–90.3)	105 (35.8–112.8)	0.62†

Diagnosis	Total N=294	Group with hypotonic solution n=151	Group with isotonic solution n=143	P value
Asthma	13	6	7	0.11‡
Acute respiratory infectious disease	109	53	56	0.72‡
Postbone marrow transplant	23	14	11	0.66‡
Postsurgical
Neurosurgical	21	10	11	0.78‡
Thoracic	25	11	14	0.26‡
Abdominal	34	19	12	0.77‡
Oncological chemotherapy plan	37	23	13	0.54‡
Seizure disorder	32	15	19	0.86‡

*Median, IQR (25–75).

†Wilcoxon test.

‡Pearson’s χ² test.