Table 2.

Results at 12 and 24 hours

	Hypotonic group	Isotonic group	P value
Patients with mild hyponatraemia (Na <135) at 12 hours	29/154 (18.8%)	12/145 (8.2%)	<0.01*
Patients with mild hyponatraemia (Na <135) at 24 hours	66/154 (42.8%)	18/145 (12.4%)	<0.01*
Patients with moderate hyponatraemia (Na <130) at 12 hours	0/154	0/145
Patients with moderate hyponatraemia (Na <130) at 24 hours	5/154 (3.2%)	0/145
Patients with metabolic acidosis (pH <7.30) at 12 hours	18/154 (11.6%)	26/145 (17.9%)	0.32*
Patients with metabolic acidosis (pH <7.30) at 24 hours	32/154 (20.7%)	38/145 (26.2%)	0.71*
Sodium serum (mEq/L) at 12 hours†	136.3 (133–139)	140.1 (138–142)	0.02‡
Sodium serum (mEq/L) at 24 hours†	134.4 (128–139)	139.3 (136–142)	0.03‡
pH in blood at 12 hours†	7.36 (7.31–7.42)	7.34 (7.27–7.40)	0.18‡
pH in blood at 24 hours†	7.39 (7.35–7.40)	7.36 (7.29–7.39)	0.31‡
Serum bicarbonate (mmol/L) at 12 hours†	23 (21–31)	24 (19–28)	0.23‡
Serum bicarbonate (mmol/L) at 24 hours†	28 (24–33)	25 (22–31)	0.19‡

Categorical variables are expressed as percentages.

*χ² test.

†Median, IQR (25–75).

‡Wilcoxon test.

Na, sodium.