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. Author manuscript; available in PMC: 2019 May 30.
Published in final edited form as: J Am Chem Soc. 2018 Oct 2;140(40):12808–12818. doi: 10.1021/jacs.8b05777

Figure 1.

Figure 1.

(left) The two pterin dithiolene ligands of the periplasmic nitrate reductase NarGHI from E. coli. The pyranopterin dithiolene is comprised of pyrimidine (C), pyrazine (B), and pyran (A) rings of the proximal MPT (red) adjacent to the [4Fe-4S] cluster FS0, and the distal MPT (blue) is bicyclic.7 Dashed lines represent hydrogen bonding interactions between Moco and FS0. A bidentate carboxylate interaction from Asp222 completes the Mo coordination sphere. PPG denotes a guanosine dinucleotide group. (right) Detailed view of Moco from NarGHI illustrating the markedly different conformations of the proximal vs distal pterin regions.