Table 4. Summary of CD4+ T helper subsets of normal subjects and non-IBC patients upon direct co-culture with control and Sdc-1-silenced SUM-149 cells.
Phenotype | Normal (n = 5) | P value | Non-IBC (n = 5) | P value | ||
---|---|---|---|---|---|---|
Control (%) | Sdc-1si (%) | Control (%) | Sdc-1si (%) | |||
Th1 | 23.8 ± 3.1 | 22.31 ± 1.6 | 1.00 | 21 ± 3.5 | 20.4 ± 2.4 | 0.72 |
Th2 | 15.54 ± 0.9 | 12.44 ± 0.7 | 0.11 | 14.6 ± 1.5 | 15.1 ± 3.6 | 0.98 |
Th17 | 25.4 ± 3.9 | 28.32 ± 2.2 | 0.24 | 26.3 ± 4.2 | 41.1 ± 5.4 | 0.03* |
Treg | 22.61 ± 3.21 | 28.98 ± 2.56 | 0.04* | 25.2 ± 4.5 | 30.6 ± 4.3 | 0.02* |
Th1/Treg | 1.1 ± 0.15 | 0.78 ± 0.04 | 0.09 | 0.87 ± 0.1 | 0.71 ± 0.08 | 0.23 |
Values represent mean percentage ± SEM. n = number of patients.
Statistically significance as determined by Student t test expressed as * P ≤ 0.05