Table 2. GO term enrichment analysis of downregulated genes.
| PANTHER GO-Slim Biological Process |
| cellular macromolecule metabolic process (GO:0044260) |
| DNA metabolic process (GO:0006259) |
| macromolecule metabolic process (GO:0043170) |
| metabolic process (GO:0008152) |
| organic substance metabolic process (GO:0071704) |
| organelle organization (GO:0006996) |
| nuclear division (GO:0000280) |
| organelle fission (GO:0048285) |
| cellular process (GO:0009987) |
| regulation of metabolic process (GO:0019222) |
| regulation of biological process (GO:0050789) |
| regulation of cell cycle (GO:0051726) |
| biological regulation (GO:0065007) |
| cell cycle process (GO:0022402) |
| DNA biosynthetic process (GO:0071897) |
| cellular component organization (GO:0016043) |
| regulation of macromolecule metabolic process (GO:0060255) |
| biosynthetic process (GO:0009058) |
| cellular component organization or biogenesis (GO:0071840) |
| macromolecule biosynthetic process (GO:0009059) |
| mitotic nuclear division (GO:0140014) |
| organic substance biosynthetic process (GO:1901576) |
| cellular macromolecule biosynthetic process (GO:0034645) |
| DNA repair (GO:0006281) |
| cell cycle (GO:0007049) |
| transcription, DNA-templated (GO:0006351) |
| regulation of gene expression (GO:0010468) |
| DNA replication (GO:0006260) |
| regulation of cellular macromolecule biosynthetic process (GO:2000112) |
| regulation of macromolecule biosynthetic process (GO:0010556) |
| regulation of biosynthetic process (GO:0009889) |
| macromolecule modification (GO:0043412) |
| meiotic nuclear division (GO:0140013) |
| regulation of organelle organization (GO:0033043) |
| cell cycle phase transition (GO:0044770) |
| regulation of mitotic cell cycle (GO:0007346) |
| transcription by RNA polymerase II (GO:0006366) |
| regulation of mitotic cell cycle phase transition (GO:1901990) |
| DNA replication initiation (GO:0006270) |
| spindle organization (GO:0007051) |
| chromosome segregation (GO:0007059) |
| chromosome organization (GO:0051276) |
| PANTHER GO-Slim Molecular Function |
| binding (GO:0005488) |
| catalytic activity (GO:0003824) |
| catalytic activity, acting on a protein (GO:0140096) |
| protein binding (GO:0005515) |
| protein kinase activity (GO:0004672) |
| DNA binding (GO:0003677) |
| pyrophosphatase activity (GO:0016462) |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) |
| hydrolase activity, acting on acid anhydrides (GO:0016817) |
| organic cyclic compound binding (GO:0097159) |
| nucleic acid binding (GO:0003676) |
| helicase activity (GO:0004386) |
| nucleoside-triphosphatase activity (GO:0017111) |
| enzyme binding (GO:0019899) |
| microtubule binding (GO:0008017) |
| DNA helicase activity (GO:0003678) |
| protein serine/threonine kinase activity (GO:0004674) |
| chromatin binding (GO:0003682) |
| tubulin binding (GO:0015631) |
| cytoskeletal protein binding (GO:0008092) |
| DNA replication origin binding (GO:0003688) |
| hydrolase activity (GO:0016787) |
| peptide N-acetyltransferase activity (GO:0034212) |
| cyclin-dependent protein kinase activity (GO:0097472) |
| cyclin-dependent protein serine/threonine kinase activity (GO:0004693) |
| double-stranded DNA binding (GO:0003690) |
| peptide-lysine-N-acetyltransferase activity (GO:0061733) |
| cysteine-type endopeptidase activity (GO:0004197) |
| acetyltransferase activity (GO:0016407) |
| histone binding (GO:0042393) |
| PANTHER GO-Slim Cellular Component |
| intracellular part (GO:0044424) |
| protein-containing complex (GO:0032991) |
| cell part (GO:0044464) |
| cell (GO:0005623) |
| catalytic complex (GO:1902494) |
| transferase complex (GO:1990234) |
| intracellular organelle part (GO:0044446) |
| nucleus (GO:0005634) |
| intracellular membrane-bounded organelle (GO:0043231) |
| membrane-bounded organelle (GO:0043227) |
| organelle (GO:0043226) |
| transferase complex, transferring phosphorus-containing groups (GO:0061695) |
| cytoplasm (GO:0005737) |
| nuclear part (GO:0044428) |
| chromosomal part (GO:0044427) |
| nucleoplasm part (GO:0044451) |
| CMG complex (GO:0071162) |
| serine/threonine protein kinase complex (GO:1902554) |
| protein kinase complex (GO:1902911) |
| MCM core complex (GO:0097373) |
| MCM complex (GO:0042555) |
| GINS complex (GO:0000811) |
| DNA replication preinitiation complex (GO:0031261) |
| protein-DNA complex (GO:0032993) |
| origin recognition complex (GO:0000808) |
| nuclear pre-replicative complex (GO:0005656) |
| pre-replicative complex (GO:0036387) |
| nuclear chromosome part (GO:0044454) |
Significantly enriched GO terms associated with the 1416 genes identified in Fig 5D, that are significantly downregulated in shRNA-BCDIN3D-no1, shRNA-BCDIN3D-no2, shRNA-BCDIN3D-no3, and shRNA-BCDIN3D-no4, but not in shRNA-white, relative to shRNA-mCherry.