Skip to main content
. Author manuscript; available in PMC: 2019 Aug 22.
Published in final edited form as: J Am Chem Soc. 2018 Aug 10;140(33):10593–10601. doi: 10.1021/jacs.8b06699

Figure 3. The effect of chiral Lewis acid co-catalysts on enantioselective coupling of an N-alkylamine and N-acryloyloxazolidinones.

Figure 3.

(a) Initial evaluation of chiral co-catalysts revealed that Mg(OTf)2/bis(oxazoline) complexes catalyze stereoselective C–C bond formation. (b) Competing B(C6F5)3-catalyzed racemic C–C bond forming reaction could deteriorate overall enantioselectivity. (c) The use of more hindered N-acryloyl oxazolidinone suppresses the racemic process to achieve C–C bond formation with higher enantioselectivity.