Key resources table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Biological sample (Macaca mulatta)	Primary simian hepatocytes	Biomedical Primate Research Centre, Netherlands		Freshly isolated from Macaca mulatta,
Biological sample (Macaca fascicularis)	Primary simian hepatocytes	SingHealth, Singapore		Freshly isolated from Macaca fascicularis
Biological sample (P. cynomolgi)	sporozoites	Armed forces research institute of medical sciences (AFRIMS) Bangkok		Anopheles dirus mosquito infected with P. cynomolgi
Biological sample (P. cynomolgi)	sporozoites	Biomedical Primate Research Centre, Netherlands		Anopheles stephensi mosquito infected with P. cynomolgi
Biological sample (P. vivax)	sporozoites	Mahidol University		Anopheles dirus mosquito infected with P. vivax
Antibody	Mouse anti-LISP2 antibody (monoclonal)	this paper		synthesized by genscript; IFA (1:500)
Antibody	Rabbit anti-PV1 antibody (polyclonal)	this paper		synthesized by genscript; IFA (1:500)
Antibody	Rabbit anti-HSP70 antibody (polyclonal)	this paper		synthesized by genscript; IFA (1:2000)
Antibody	Rabbit anti-H3K9ac antibody (monoclonal)	Abcam,	ab177177	IFA (1:1000)
Antibody	Alexa 488-conjugated goat anti-rabbit immunoglobulin (polyclonal)	Invitrogen	11034	IFA (1:4000)
Antibody	Alexa 594-conjugated goat anti-mouse immunoglobulin (polyclonal)	Invitrogen	11032	IFA (1:5000)
Sequence- based reagent	RNA FISH probes	this paper		Synthesized by Advanced Cell Diagnostics
Commercial assay or kit	CCK-8 kit	Sigma	96992 100TESTS-F
Chemical compound, drug	KDU691	Novartis internal chemical library		Synthesized by Novartis
Chemical compound, drug	Atovaquone (ATQ)	Novartis internal chemical library		Synthesized by Novartis
Chemical compound, drug	Tafenoquine (TQ)	Novartis internal chemical library		Synthesized by Novartis
Chemical compound, drug	DMSO	Sigma	D8418