Table 2.

Linear regression models showing the associations of demographic, pathological and/or overall brain neurochemical variables, with global cognitive function in MAP participants by Braak stage

Model and terms	Braak 0–II		Braak III–IV		Braak V–VI
	Adj. R2 or Ba	P value	Adj. R2 or B	P value	Adj. R2 or B	P value
Reference model	0.3413		0.2259		0.2307
Sex	0.2204	0.0063*	−0.0541	0.3023	0.2829	0.0160*
Age at death	−0.0088	0.4265	−0.0242	0.0062*	−0.0416	0.0827
Education	0.0636	0.0241*	0.0240	0.1685	0.0109	0.7813
PMI	−0.0056	0.7385	0.0036	0.7676	0.0237	0.2484
Macroinfarcts	−0.2327	0.1924	−0.5147	<.0001*	0.0103	0.9628
Lewy bodies	−0.4268	0.0682	−0.1392	0.2609	0.0418	0.8677
Hippocampal sclerosis	−1.1800	<.0001*	−0.5474	0.0017*	−0.8913	0.0405*
β-amyloid	−0.0936	0.2467	−0.0244	0.5628	−0.0561	0.6838
Phosphotau	−0.0432	0.6785	−0.0460	0.0019*	−0.0513	<.0001*
Synapse densityb	0.0111	0.9108	−0.0559	0.2768	−0.0848	0.5023
Test model	0.4852		0.2216		0.3036
Sex	0.2117	0.0037*	−0.0532	0.3137	0.3542	0.0022*
Age at death	−0.0132	0.1850	−0.0234	0.0088*	−0.0326	0.1565
Education	0.0693	0.0087*	0.0226	0.1990	0.0422	0.2742
PMI	−0.0101	0.4999	0.0033	0.7891	0.0327	0.0987
Macroinfarcts	−0.1726	0.2749	−0.5094	<.0001*	0.0113	0.9568
Lewy bodies	−0.6308	0.0039*	−0.1239	0.3248	0.1231	0.6088
Hippocampal sclerosis	−0.7454	0.0069*	−0.5320	0.0028*	−0.8319	0.0478*
β-amyloid	−0.0374	0.6081	−0.0241	0.5690	−0.0494	0.7069
Phosphotau	−0.0575	0.5454	−0.0442	0.0033*	−0.0518	<.0001*
Synapse densityb	−0.1581	0.1615	−0.0682	0.2435	−0.2149	0.0964
CPX1	0.5466	0.0001*	0.0748	0.4171	−0.1476	0.3228
CPX2	0.2355	0.1241	−0.0284	0.7323	0.5189	0.0022*

^aUnstandardized coefficient

^bSynapse density was estimated as the overall brain levels of the three SNARE proteins (syntaxin-1, SNAP-25 and VAMP) averaged

^*Statistically significant