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. 2019 May 16;4(10):e125052. doi: 10.1172/jci.insight.125052

Figure 10. scAAV.CNP.Venus.Plp1miRNA treatment improved microgliosis in Plp1-Tg mice.

Figure 10

(A) Immunostaining for microglia marker Iba1 in the brain sections from P25 Wt+miRneg mice (top row), Tg+miRneg mice (middle row), and Tg+Plp1miRNA mice (bottom row). Low-magnification images (first and second columns, scale bar: 1 mm) and high-magnification images (scale bar: 50 μm) of the CC (third column) and IC (fourth column) are shown. (B) The percentages of amoeboid microglia in total Iba1-positive cells were examined in CC sections and IC sections (n = 5 mice per group). Statistical significance was determined using 1-way ANOVA with Bonferroni’s post hoc test. *P < 0.05; **P < 0.01; ***P < 0.001.