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. 2019 May 16;4(10):e125052. doi: 10.1172/jci.insight.125052

Figure 4. scAAV.CNP.Venus.Plp1miRNA treatment extended the lifespan and improved weight gain of Plp1-Tg mice.

Figure 4

(A) Survival curves of Tg+miRneg mice (black line, n = 16 mice) and Tg+Plp1miRNA mice (gray line, n =18 mice). Data from WT mice are not shown because no mouse died during the course of the study regardless of treatment. Statistical significance was determined using the Kaplan-Meier method combined with a generalized Wilcoxon test. (B) Body weight changes are shown for Wt+miRneg mice (open circle, n = 9 mice), for Tg+miRneg mice (closed triangle, n = 16 mice), and for Tg+Plp1miRNA mice (gray triangle, n = 18 mice). Statistical significance was determined using 1-way ANOVA with Bonferroni’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001.