Figure 7. RocA treatment impairs ERK activation in an ALK-mutant, patient-derived xenograft in vivo.

(A) Heatmaps showing excess over Bliss synergy scores for combination treatment with RocA and trametinib in neuroblastoma cells. Values greater than 1 (shown in red) denote synergistic combinations while values less than 1 (shown in green) denote antagonistic combinations. Data represent 3 technical triplicates. (B) Dosing schedule of RocA, trametinib, and vehicle controls for patient-derived xenograft treatment. (C) Western blot analysis of patient-derived xenografts of mice treated with RocA, trametinib, or RocA and trametinib combination treatment compared with vehicle control–treated mice.