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. Author manuscript; available in PMC: 2019 May 30.
Published in final edited form as: ACS Catal. 2018 Mar 20;8(4):3532–3549. doi: 10.1021/acscatal.8b00624

Table 2. Multi-step biocatalysis and chemo-enzymatic routes to industrially-useful compounds.

Entry Final product (s) Uses ER(s) Other enz. Ref.
1 Inline graphic
4-methylheptan-3-ol1 		Insect pest management OYE2.6 OYE1 W116V ADH440 ADH270 66
2 Inline graphic
3-Methyl-4-pentanolide1 		Fragrance industry OYE2 KRED READH 67
3 Inline graphic
R=Ac, Bz, Bn		 Precursors of drugs, flavours, and agrochemicals OYE3 EVO030 EVO270 68
4 Inline graphic
R1=Me, Ph, NHCHO; R2=Et, Ph, 4-Cl-Ph		 Cosmetics, food additives, and pharmaceuticals OYE2 EcAldDH 12
5 Inline graphic
R=H, OH, OMe		 Antioxidants and flavor enhancers sERED CHI 69
6 Inline graphic
Butanol		 Biofuel YqjM PDC, ADH 70
7 Inline graphic
(R) and (S) forms		 Industrially-useful synthons YqjM C26D/I69T variant ATA 71
1

Four stereoisomers produced.

*

Highlighted chiral centres. ER sources: OYE2.6 = P. stipitis; OYE1 = Saccharomyces pastorianus. Other enz = other biocatalysts utilised within the cascading reactions, excluding cofactor regenerating enzymes.