Table 1. Characteristics of nursing mother-infant pairs.
| Mothers (n = 134)a | |
| Age (y) | 29 (18-44) |
| Weight (kg) | 57 (39-80) |
| Time since diagnosis (months) | 21.1 (1.3-68) |
| Infants (n = 134)a | |
| Age (weeks) | 20.0 (0.29-75) |
| Weight (kg) | 5.8 (2.2-10) |
| Gender (Female) | 52% (70/134) |
| Maternal drug regimen and CD4 counta | |
| TDF/FTC/EFV | 65% (87/134) |
| 3TC/AZT/EFV | 32% (43/134) |
| 3TC/TDF/EFV | 2% (3/134) |
| 3TC/ABC/EFV | 1% (1/134) |
| Time post dose (h)b | 11.8 (5.5) |
| Duration on regimen (months)b | 17.6 (14.1) |
| Baseline CD4 count (c/mm3)b | 380 (217) |
| CD4 change (c/mm3)b | 177 (217) |
| Maternal genotype frequency: | |
| CYP2B6 516G>T (rs3745274) | GG, 0.36; GT, 0.45; TT, 0.19 |
| CYP2B6 983T>C (rs28399499) | TT, 0.79; CT, 0.21; CC, 0.00 |
| CYP2B6 c.485-18C>T (rs4803419) | CC, 0.79; CT, 0.21; TT, 0.00 |
| NR1I3 c.540C>T (rs2307424) | CC, 0.77; CT, 0.23; TT, 0.00 |
| NR1I3 c.152-1089T>C (rs3003596) | TT, 0.19; CT, 0.54; CC, 0.27 |
| ABCB1 4046A>G (rs1045642) | AA, 0.75; AG, 0.25; GG, 0.00 |
| ABCB1 4036A>G (rs3842) | AA, 0.65; AG, 0.35; GG, 0.01 |
| ABCB1 1236C>T (rs1128503) | CC, 0.76; CT, 0.23; TT, 0.02 |
| CYP2A6 48T>G (rs28399433) | TT, 0.93; GT, 0.07; GG, 0.01 |
| ABCB5 c.2908G>A (rs6461515) | GG, 0.45; GA, 0.45; AA, 0.10 |
| ABCG2 c.1728-46G>A (rs2231164) | GG, 0.68; GA, 0.30; AA, 0.02 |
| ABCG2 78551A>G (rs2622604) | AA, 0.84; AG, 15; GG, 0.01 |
| Infants’ genotype frequency: | |
| CYP2B6 516G>T (rs3745274) | GG, 0.45; GT, 0.67; TT, 0.18 |
a
Unless otherwise indicated, values are expressed as median (range) or % (number) of subjects;
b
mean (standard deviation).