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Depiction of a resting healthy IgM-expressing B cell in an uninfected individual and changes that occur during chronic HIV-1 infection in affected individuals. During chronic HIV-1 viremia, inhibitory Fc receptor CD32b expression increases and becomes associated with IgG3-IgM-BCR microclusters, along with C1q and CRP. The clustering occurs predominantly in TLM B cells and involves direct interactions between IgG3 and the IgM-BCR. P, phosphorylated.
