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. 2019 Feb 14;38(22):4366–4383. doi: 10.1038/s41388-019-0728-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Correlation of tumour SPARC and cEBPβ, NFkB, and AP-1. a Photomicrograph of stage III HGSC specimens (CHTN) showing distinctive compartmentalization of SPARC in the cancerous vs stromal compartments and the expression of cEBPβ, NFkB, and cJun. b Scatter plots of the expression scores of SPARC, cEBPβ, NFkB, and cJun. p < 0.05, Mann–Whitney test. c Spearman’s correlation of the expression scores of tumour-SPARC and nuclear transcription factors. d Immunofluorescence staining of the expression of omental metastases of HGSC specimens, showing the expression of cEBPβ, RelA, cJun, and SPARC in the tumour (T)–adipocyte (A) interface. e Spearman’s correlation of the nuclear expression of tumour and adipocyte cEBPβ, RelA, and cJun with tumour and adipocyte SPARC. Scale bars 100 µm