Table 2. Univariate and multivariate Cox regression of prognostic factors for DFS in retinoblastoma patients.

Parameter	Univariate analysis			Multivariate analysis
	HR	95%CI	P	HR	95%CI	P
Age (years)
≤2 vs. >2	1.072	0.517–2.224	0.851
Gender
Male vs. Female	1.059	0.506–2.218	0.879
Choroidal invasion
No vs. Yes	3.218	1.476–7.018	0.003	1.464	0.543–3.946	0.452
Optic nerve invasion
No vs. Yes	3.150	1.493–6.646	0.003	2.315	1.024–5.230	0.044
Laterality
Unilateral vs. Bilateral	1.972	0.918–4.235	0.082
Pathologic grade
Well differentiated vs. Poorly differentiated	0.562	0.269–1.176	0.126
FEZF1-AS1
Low vs. High	3.703	1.703–8.052	0.001	2.618	1.008–6.802	0.048

Abbreviations: HR, hazard ratio; 95%CI, 95% confidence interval.