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. 2019 May 26;12(8):1015–1025. doi: 10.1016/j.tranon.2019.05.003

Figure 6.

Figure 6

SRCi increases the antitumor activity of JAKi in mice. (A-C) MDAH2774 cells were implanted into the peritoneal cavity of female athymic nude mice. Tumors were treated daily with vehicle, JAKi (20 mg/kg), SRCi (15 mg/kg), or their combination by oral gavage. Mice were euthanized 4 weeks later. The tumor nodules throughout the peritoneal cavity were excised and weighed (A). Ascites were collected, and the volumes were measured (B). Representative tumors were photographed (C). The percentage of treated compared to vehicle controlled were calculated (C). Data represents means ± SD (n = 4-10).*, P < .05, **, P < .005, ****, P < .0001, NS, not significant.