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. 2018 Nov 27;9(3):526–536. doi: 10.1016/j.apsb.2018.11.004

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Fig. 1 — OCA treatment decreases BAs levels via activating FXR signaling. (A)–(C) OCA treatment in healthy mice could successfully activate FXR signal and thereby inhibiting BA synthesis (n = 5). (A) Expression of FXR and its target genes in the liver. Serum total BA levels (B) and profiles (C). (D)–(F) OCA treatment reversed the dysregulation of FXR signal and dyshomeostasis of BAs in CCl₄-treated mice (n = 5). (D) Expression of FXR and its target genes in the livers. Serum total BAs levels (E) and profiles (F). Results are mean ± SD (n = 5), ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^#P < 0.05, ^##P < 0.01, ^###P < 0.001.