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. 2018 Nov 27;9(3):526–536. doi: 10.1016/j.apsb.2018.11.004

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Fig. 3 — OCA is not effective against hepatocyte apoptosis. (A)–(B) OCA failed to prevent hepatocyte apoptosis induced by CCl₄ (n = 5). (A) TUNEL staining of liver sections. (B) Caspase activities of liver homogenate. (C)–(F) OCA failed to prevent GalN/LPS-induced apoptosis (n = 5). (C) Serum ALT and AST levels. (D) Caspase activities of liver homogenate. H&E (E) and TUNEL (F) staining of liver sections. (G)–(I) OCA failed to prevent CHX/TNFα-induced HepG2 apoptosis in vitro as indicated by MTT assay (G), annexin V–PI staining (H) and caspase activities (I). Results are mean ± SD, ^**P < 0.01, ^***P < 0.001.