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BAs and apoptotic hepatocytes trigger HSC activation and proliferation. Effect of BAs (A) and apoptotic hepatocyte co-culture (B) on HSC activation was measured by the expression profiling of pro-fibrotic genes (n = 3). Effect of BAs (C) and apoptotic hepatocyte co-culture (D) on the proliferation of HSCs as assessed by BrdU assay (n = 3). Results are mean ± SD, *P < 0.05, **P < 0.01, ##P < 0.01, ###P < 0.001.
