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Liver fibrosis and cirrhosis are characterized with elevated BAs and hepatocyte apoptosis. Serum from liver fibrotic patients (n = 20), cirrhotic patients (n = 30) as well as healthy donors (n = 20) were collected. Serum total BA levels (A) and BA profiles as analyzed (B). Hepatocyte apoptosis was assessed by TUNEL staining of liver biopsy (C) and serum CK-18 (M30) levels (D). Results are mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001.
