Fig. 6.

Adipose-specific HuR deletion exacerbates insulin resistance. a, b Glucose tolerance test (a) and insulin tolerance test (b) in control and HuR^AKO mice fed an HFD (n = 10), *comparison of HuR^AKO vs. control. Right panel, area under curve. c, d Western blot analysis of Akt phosphorylation and HuR in adipose tissue, liver and muscle of control and HuR^AKO mice with HFD. Protein levels were normalized to GAPDH level (n = 5), *comparison of HuR^AKO vs. control. e, f Serum insulin and adiponectin levels in overnight-fasted control and HuR^AKO mice fed an HFD (n = 5), *comparison of HuR^AKO vs. control. Data are represented as mean ± SEM. Significance was determined by Student’s t test analysis, *P < 0.05. Source data are provided as a Source Data file