. 2019 Feb 27;12(2):147–155. doi: 10.1007/s12178-019-09543-9

Table 4.

List of documented NSAIDs prophylactic regiments in the recent literature 2014–2018

Generic drug name (brands)	Dose, frequency, and duration	Advantages	Disadvantages
Naproxen (Naprosyn)	500 mg BID for 3 weeks	• Nonselective COX-inhibitor, less cardiac risks [22]. • Efficacy has been studied and is high [1••, 7•]	• Nonselective COX-inhibitor, more GI risks [23] • Less compliance (GI upset)
Etodolac (Lodine)	600 mg daily for 2 weeks	• Selective COX-2 inhibitor, more cardiac risks [22] • One-day dose (increases compliance) • Lower duration	• Selective COX-2 inhibitor, less GI irritation increases compliance [23]
Acetylsalicylic acid (Aspirin)	325 mg BID for 6 weeks	• Nonselective COX-inhibitor, less cardiac risk [22] • Added VTE prophylaxis benefit	• Nonselective COX-inhibitor, more GI risk [23] • Platelet inhibitor, bleeding risk

Generic drug name (brands)

Dose, frequency, and duration

Advantages

Disadvantages

Naproxen (Naprosyn)

500 mg BID for 3 weeks

• Nonselective COX-inhibitor, less cardiac risks [22].

• Efficacy has been studied and is high [1••, 7•]

• Nonselective COX-inhibitor, more GI risks [23]

• Less compliance (GI upset)

Etodolac (Lodine)

600 mg daily for 2 weeks

• Selective COX-2 inhibitor, more cardiac risks [22]

• One-day dose (increases compliance)

• Lower duration

• Selective COX-2 inhibitor, less GI irritation increases compliance [23]

Acetylsalicylic acid (Aspirin)

325 mg BID for 6 weeks

• Nonselective COX-inhibitor, less cardiac risk [22]

• Added VTE prophylaxis benefit

• Nonselective COX-inhibitor, more GI risk [23]

• Platelet inhibitor, bleeding risk

VTE, venous thromboembolism; BID, twice daily; COX, cyclooxygenase; mg, milligrams