Table 2.
(KFF)3K | PNA5079 8-mer |
PNA5080 9-mer |
PNA2108 10-mer |
PNA5082 11-mer |
PNA5083 12-mer |
|||||
---|---|---|---|---|---|---|---|---|---|---|
Match | mm | Match | mm | Match | mm | Match | mm | Match | mm | |
MG1655 | 4 | 16 | 2–4 | 16 | 0.5–1 | 16 | 4 | 16 | 4 | 16 |
MG1655(ΔsbmA) | 16 | 16–32 | 16 | 16 | 8–16 | 16–32 | 16 | 16 | 16 | 16 |
AS19 | 0.5 | 2 | 0.5 | 2 | 0.125 | 1–2 | 0.5 | 2 | 0.5 | 2 |
ATCC25922 (ΔrfaG) | 0.25 | >8 | nd | nd | 0.125 | 4 | >0.25 | >1 | 1–2 | 1–2 |
Klebsiella pneumoniae | 8–16 | >32 | nd | nd | 2 | >32 | nd | nd | 8 | >32 |
MIC values (μM) of 8–12-mer match or mismatch (italicized) anti-acpP PNA conjugate. nd, Not determined.