Table 4.

Mixed-effects linear regression model of the longitudinal association of the microcirculation and postnatal days of life.

	GA adjusted coefficient (95% CI)*	p-value+	Multivariable adjusted coefficient (95% CI)**	p-value+
FVD	−0.03 (−0.11–0.05)	0.424	−0.08 (−0.16–0.01)	0.033
VS	−0.07 (−0.18–0.03)	0.162	−0.11 (−0.21–0.06)	0.063
Dia S	0.25 (−0.21–0.71)	0.279	0.20 (−0.28–0.68)	0.412
Dia M	−0.26 (−0.70–0.18)	0.255	−0.21 (−0.67–0.25)	0.370
Dia L	0.002 (−0.03–0.03)	0.900	0.01 (−0.02–0.05)	0.489
MFI	−0.005 (−0.02–0.15)	0.646	0.003 (−0.02–0.03)	0.816

^*Fitted model: estimated microcirculatory parameters = ß₀ + ß₁ * days of life + ß₂^* gestational age at birth; ß₀: intercept-term model; the model is taking into account the longitudinal microcirculatory measurements in the preterm cohort.

⁺Statistically significant results (except for intercept term) are displayed in bold.

^**Fitted multivariable adjusted model: estimated microcirculatory parameters = ß₀ + ß₁^* days of life + ß₂^* gestational age at birth + ß₃^* mean arterial blood pressure + ß₄^* heart rate + ß₅^* oxygen saturation + ß₆^* body temperature; ß₀: intercept-term.