Table 2.

GWAS genetic data sets used in the Mendelian randomization analysis in the main text.

Traits	PubMed ID	Population	k	p	Sample size	Data source
BMI	30124842	European	1,031	2,336,269	773,253	GIANT (52)
ALS	29566793	European		10,031,417	80,610	(4)
BMI	28892062	East Asian	75	6,108,953	158,284	BioBank Japan (50)
ALS	28931804	East Asian		6,613,544	4,084	(57)

BMI, body mass index; ALS, amyotrophic lateral sclerosis; k is the number of instruments and p is the total number of SNPs in the GWAS genetic data. Note that there were ~41,000 and ~5,000 BMI-associated SNPs (p < 5E−8) in the European and East Asian GWAS genetic data sets, the shared number of BMI-associated SNPs was ~1,100.