Table 1.

Clinical characteristics of conjunctival melanoma treated with IFN-α2b.

Number	Age	Gender	Size (mm)	Location	Origin	Color	TMN	Depth of invasion (mm)	Histopathology	Surgical margins	Duration of IFN-α2B therapy (months)	Outcome	Recurrence after initial IFN-α2B therapy	Follow up duration (months)
1	59	F	8 × 4	Bulbar	PAM with atypia	Amelanotic	pT1cN0M0	1.49	Epithelioid	Positive PAM with atypia at inferior margins	6	Remission	N/A	54
2	32	F	1 × 1	Bulbar	Compound nevus	Pigmented	pT1isN0M0	1	Epithelioid	Positive PAM with atypia at horizontal margins	6	Remission	N/A	33
3	91	F	7 × 7	Bulbar	PAM	Pigmented with feeder vessels	pT1cN0M0	3.45	Epithelioid	Invasive melanoma at deep and limbal borders. PAM at temporal and inferior borders	6	Recurrence with metastatic disease to lung, mediastinum and pelvis at 7 months. Ultimately passed away	Seven months following initial resolution of pigment had ptosis. Pathology showed lacrimal gland mass infiltrating the lateral rectus muscle identical to previous biopsy.	N/A
4	63	M	4 × 7	Superior and nasal bulbar	Compound nevus	Pigmented	Not enough information	0.43	Spindle	Invasive melanoma at all horizontal borders	6	Incomplete regression after 6 months of therapy	Six months after therapy had recurrence of pigmentation on superior conjunctiva. Pathology showed infiltrating melanoma with PAM with atypia at superior margin with melanoma in-situ at nasal margin. Treated with excisional biopsy with MMC.	14
5	59	F	1.5 × 1.7	Nasal bulbar	PAM	Pigmented	pT1aN0M0	0.39	Epithelioid	Invasive melanoma at all horizontal borders and possibly deep margin	3	No response and ultimate enucleation	Rebiopsy after lack of response to treatment showed malignant melanoma with positive deep and limbal margins.	12