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. 2019 May 22;15:100467. doi: 10.1016/j.ajoc.2019.100467

Table 1.

Clinical characteristics of conjunctival melanoma treated with IFN-α2b.

Number Age Gender Size (mm) Location Origin Color TMN Depth of invasion (mm) Histopathology Surgical margins Duration of IFN-α2B therapy (months) Outcome Recurrence after initial IFN-α2B therapy Follow up duration (months)
1 59 F 8 × 4 Bulbar PAM with atypia Amelanotic pT1cN0M0 1.49 Epithelioid Positive PAM with atypia at inferior margins 6 Remission N/A 54
2 32 F 1 × 1 Bulbar Compound nevus Pigmented pT1isN0M0 1 Epithelioid Positive PAM with atypia at horizontal margins 6 Remission N/A 33
3 91 F 7 × 7 Bulbar PAM Pigmented with feeder vessels pT1cN0M0 3.45 Epithelioid Invasive melanoma at deep and limbal borders. PAM at temporal and inferior borders 6 Recurrence with metastatic disease to lung, mediastinum and pelvis at 7 months. Ultimately passed away Seven months following initial resolution of pigment had ptosis. Pathology showed lacrimal gland mass infiltrating the lateral rectus muscle identical to previous biopsy. N/A
4 63 M 4 × 7 Superior and nasal bulbar Compound nevus Pigmented Not enough information 0.43 Spindle Invasive melanoma at all horizontal borders 6 Incomplete regression after 6 months of therapy Six months after therapy had recurrence of pigmentation on superior conjunctiva. Pathology showed infiltrating melanoma with PAM with atypia at superior margin with melanoma in-situ at nasal margin. Treated with excisional biopsy with MMC. 14
5 59 F 1.5 × 1.7 Nasal bulbar PAM Pigmented pT1aN0M0 0.39 Epithelioid Invasive melanoma at all horizontal borders and possibly deep margin 3 No response and ultimate enucleation Rebiopsy after lack of response to treatment showed malignant melanoma with positive deep and limbal margins. 12
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