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Relative levels of CXCR4. mRNA expression. Mann–Whitney analysis revealed statistical significant differences between (A) primary OS and healthy bone tissue, (B) low and high grade OS, (C) disease-free and relapsed OS. (D) Kaplan–Meier analysis based on CXCR4 expression showed a higher probability of disease-free survival in patients with low CXCR4 mRNA levels. Cut-off rounded to the 50°percentile. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001.
