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. 2019 Apr 4;9(3):469–483. doi: 10.1016/j.apsb.2019.03.007

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Fig. 3 — (A) Dissolvable microneedle arrays made from HA containing chemotherapeutic drug DOX were integrated with gold nanocages followed by exposure to NIR light to combine chemotherapy with photothermal therapy for synergistically treating superficial tumors. Reproduced with permission from Ref. 71. Copyright © 2016, American Chemical Society. (B) A microneedle platform based on HA was encapsulated anti-PD1 antibody to combine with the PD1 and 1-MT to inhibit IDO for melanoma immunotherapy. Reproduced with permission from Ref. 30. Copyright © 2018, American Chemical Society. (C) A light-activatable microneedle patch was composed of dissolvable PVA/PVP as supporting material containing polycaprolactone formulation, which consisted of photothermal nanoparticles and an antitumor drug for treating skin tumors synergistically. While exposed to NIR light, the microneedle patch was melted at 50 °C to release DOX for locoregional cancer therapy. Reproduced with permission from Ref. 74. Copyright © 2015, American Chemical Society. (D) The polymeric polyvinylpyrrolidone microneedle patch brought together two main components including the peptide RALA and DNA vaccine for the treatment of cervical cancer. Reproduced with permission from Ref. 77. Copyright © 2017, Elsevier.