Table 1. Characteristics associated with patients with BRCA negative and VUS mutations.
| Characteristics | Negative | VUS | p-value | |
|---|---|---|---|---|
| Age at testing, Median (Range) | 46 (26–79) | 46 (26–79) | ||
| VUS type | - | 99 | ||
| Unknown | - | 79 (80) | ||
| Favor polymorphism | - | 18 (18) | ||
| Suspect deleterious | - | 2 (2) | ||
| Race | 0.000 | |||
| Non-caucasian | 15 (15) | 45 (46) | ||
| Caucasian | 74 (75) | 44 (44) | ||
| Not reported | 10 (10) | 10 (10) | ||
| Ethnicity | 0.000 | |||
| Ashkenazi | 43 (43) | 75 (76) | ||
| Non-Ashkenazi | 37 (37) | 11 (11) | ||
| Not reported | 19 (19) | 13 (13) | ||
| Parity | 0.101 | |||
| 0 | 40 (40) | 29 (29) | ||
| ≥1 | 59 (60) | 70 (71) | ||
| Menopausal status | 0.155 | |||
| Premenopausal | 68 (69) | 54 (56) | ||
| Perimenopausal | 4 (4) | 10 (10) | ||
| Postmenopausal | 25 (25) | 32 (32) | ||
| Unknown | 2 (2) | 3 (3) | ||
| OCPs prior to RRBSO | 0.054 | |||
| Yes | 56 (57) | 39 (39) | ||
| No | 20 (20) | 28 (28) | ||
| Unknown | 23 (23) | 32 (32) | ||
| Personal history of breast cancer* | 74 (75) | 79 (80) | 0.396 | |
| Personal history of gynecologic cancer* | 1 (1) | 3 (3) | 0.621 | |
| Family history of breast cancer* | 65 (66) | 64 (68) | 0.878 | |
| Family history of all gynecologic cancers* | 20 (20) | 18 (19) | 0.312 | |
| Family history of ovarian cancer* | 19 (19) | 12 (12) | 0.171 | |
| RRBSO | 0.305 | |||
| No | 80 (81) | 74 (76) | ||
| Yes | 19 (19) | 25 (25) | ||
Values are presented as number (%).
Chi-square and Fisher's exact tests for small cells for categorical variables, and t-tests for continuous variables.
VUS, variants of unknown significance; OCP, oral contraceptive pills; RRBSO, risk-reducing bilateral salpingo-oophorectomy.
*Patients with unknown cancer history were excluded from this analysis.