Table 2. Characteristics associated with patients undergoing RRBSO.
| Characteristics | No RRBSO (n=154) | RRBSO (n=44) | p-value | |
|---|---|---|---|---|
| Age at testing, Median (Range) | 46 (26–79) | 47.5 (30–67) | ||
| Variant type | 0.603 | |||
| Negative | 80 (52) | 19 (43) | ||
| Unknown | 59 (38) | 20 (46) | ||
| Favor polymorphism | 14 (9) | 4 (9) | ||
| Suspect deleterious | 1 (1) | 1 (2) | ||
| Race | 0.095 | |||
| Non-caucasian | 98 (64) | 20 (46) | ||
| Caucasian | 42 (27) | 18 (41) | ||
| Not reported | 14 (9) | 6 (14) | ||
| Ethnicity | 0.023 | |||
| Ashkenazi | 88 (57) | 30 (68) | ||
| Non-Ashkenazi | 44 (29) | 4 (9) | ||
| Not reported | 22 (14) | 10 (23) | ||
| Parity | 0.403 | |||
| 0 | 56 (36) | 13 (30) | ||
| ≥1 | 98 (64) | 31 (71) | ||
| Menopausal status | 0.216 | |||
| Premenopausal | 99 (64) | 23 (52) | ||
| Perimenopausal | 10 (7) | 4 (9) | ||
| Postmenopausal | 40 (26) | 17 (39) | ||
| Unknown | 5 (3) | 0 (0) | ||
| OCPs prior to RRBSO | 0.520 | |||
| Yes | 77 (50) | 18 (41) | ||
| No | 35 (23) | 13 (30) | ||
| Unknown | 42 (27) | 13 (30) | ||
| Personal history of breast cancer* | 117 (76) | 36 (82) | 0.415 | |
| Personal history of gynecologic cancer* | 3 (1) | 1 (2) | 1.000 | |
| Family history of breast cancer* | 100 (67) | 29 (67) | 0.924 | |
| Family history of all gynecologic cancers* | 26 (17.3) | 12 (28) | 0.124 | |
| Family history of ovarian cancer* | 20 (13) | 11 (25) | 0.053 | |
Values are presented as number (%).
Chi-square and Fisher's exact tests for small cells for categorical variables, and t-tests for continuous variables. For family history, patients with unknown family histories were excluded.
RRBSO, risk-reducing bilateral salpingo-oophorectomy; OCP, oral contraceptive pills.
*Patients with unknown cancer history were excluded from this analysis.