Fig. 10.

Mapping of nitration sites to laminin-111 crystal structures. Nitration sites identified are mapped to resolved crystal structures of laminin-111 domains. Colors indicate the cluster assigned to the nitration sites based on their extent of modification: Red: Cluster A, very extensively modified sites, Orange: Cluster B, extensively modified sites, Black: Cluster C, moderately modified sites, Grey: Cluster C, mildly modified sites. The crystal structures shown are resolved for: A) the N-terminal domain of the laminin-$\beta 1$ chain [62]; B) the N-terminal domain of the laminin-$\gamma 1$ chain [62]; C) the C-terminal part of the laminin-111 heterotrimer [65]; D) as C), but with all the acidic residues indicated in blue. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)