Fig. 7.

Effect of CO₂ on laminin-111 nitration. Panel A): the extent of laminin-111 nitration in the presence (blue bars) or absence (black bars) of CO₂ was estimated by summing occupancies for all 6-nitroTrp sites (upper left panel), 3-nitroTyr sites (upper right panel), 4,6-dinitroTrp sites (lower left panel) and 3,5-dinitroTyr sites (lower right panel), respectively. Values are expressed as means ± SEM (n = 3). Asterisks indicate significant differences between samples (Students t-test, *p < 0.05, **p < 0.01, ***p < 0.001). Panel B) Differences in site-specific formation of nitration (black symbols) or di-nitration (red symbols) given as log2 fold-change between the presence and absence of CO₂. Only sites where the differences were statistically significant (t-test with false discovery rate correction, p < 0.05) are shown. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)