Fig. 6.

Anti-IC activities of curcumol on CPS-lesioned mice. As showed in HE stains, CPS-lesioned mice resulted in morphological changes in bladder tissues. And increased expression of intracellular TNF-α in the bladder were observed in CPS-lesioned mice by using immunohistochemical stain. Interestingly, curcumol-treated mice showed bladder morphological improvement, and reduced TNF-α expression. As showed in immunofluorescence staining, CPS-lesioned mice resulted in elevated PTK2, p-PTK2^Tyr397 expressions in bladder sections. However, down-regulated expressions of TNF-α, PTK2, p-PTK2^Tyr397 in the bladder cells of curcumol-treated mice were observed, accompanied with ameliorative histomorphology in bladder tissues.