Figure 7.

(A) Schematic illustration of fabrication process of nerve conduit with aligned fibers for axon outgrowth direction guidance and neurotrophic concentration gradient to attract the regenerated axon. (B–E) Nerve regeneration in the rabbit sciatic nerve transection model. (B) Sciatic nerve before surgery. (C–E) After surgical implantation of multichanneled scaffold combined with aligned nanofibers and neurotrophic gradient (MC/AN/NG) nerve conduit for 8, 16, and 24 weeks, the repaired nerve was clearly observed. The arrowhead indicates the regenerated sciatic nerve. (P, proximal end; D, distal end). Reproduced from Chang et al. (2017) with permission from American Chemical Society.