Table 3.
The brain segmental volumes of CS and NC participants.
| Measurement (ANIMAL segmentation number) | CS (N = 10) Mean [SD] (mm3) | NC (N = 20) Mean [SD] (mm3) | The rate of CS/NC | p | AbsoluteCohen's d |
|---|---|---|---|---|---|
| L frontal GM (210) | 168,135 [50458] | 145,075 [25648] | 1.16 | 0.20 | 0.65 |
| R frontal GM (211) | 167,102 [49908] | 147,094 [26283] | 1.14 | 0.26 | 0.56 |
| L frontal WM (30) | 87,020 [31074] | 99,598 [21739] | 0.87 | 0.21 | 0.5 |
| R frontal WM (17) | 87,843 [33812] | 98,408 [21402] | 0.89 | 0.30 | 0.41 |
| L temporal GM (218) | 111,633 [28653] | 98,517 [12350] | 1.13 | 0.19 | 0.68 |
| R temporal GM (219) | 113,504 [30448] | 101,863 [13403] | 1.11 | 0.27 | 0.57 |
| R temporal WM (59) | 47,142 [17995] | 53,762 [9348] | 0.88 | 0.19 | 0.52 |
| L temporal WM (83) | 45,419 [15959] | 51,630 [8117] | 0.88 | 0.17 | 0.55 |
| L parietal GM (6) | 88,487 [27282] | 76,648 [13902] | 1.15 | 0.22 | 0.62 |
| R parietal GM (2) | 85,008 [24509] | 76,392 [14222] | 1.11 | 0.32 | 0.47 |
| L parietal WM (57) | 51,127 [21035] | 55,635 [10441] | 0.92 | 0.44 | 0.31 |
| R parietal WM (105) | 49,406 [19316] | 55,430 [10600] | 0.89 | 0.28 | 0.43 |
| L occipital GM (8) | 41,470 [14087] | 39,492 [6010] | 1.05 | 0.68 | 0.21 |
| R occipital GM (4) | 43,012 [13971] | 39,514 [6259] | 1.09 | 0.47 | 0.37 |
| L occipital WM (73) | 21,186 [9708] | 25,635 [5753] | 0.83 | 0.12 | 0.61 |
| R occipital WM (45) | 21,617 [8501] | 25,225 [5938] | 0.86 | 0.19 | 0.53 |
| L thalamus (102) | 7156 [1038] | 7571 [1006] | 0.95 | 0.30 | 0.41 |
| R thalamus (203) | 7484 [896] | 7572 [981] | 0.99 | 0.82 | 0.09 |
| L caudate (39) | 4674 [865] | 4733 [779] | 0.99 | 0.85 | 0.07 |
| R caudate (53) | 5030 [1277] | 4743 [743] | 1.06 | 0.44 | 0.3 |
| L fornix (29) | 554 [304] | 684 [127] | 0.81 | 0.22 | 0.64 |
| R fornix (254) | 533 [295] | 662 [112] | 0.81 | 0.21 | 0.68 |
| L globus pallidus (12) | 887 [217] | 1084 [131] | 0.82 | 0.021 | 1.21 |
| R globus pallidus (11) | 903 [188] | 1042 [138] | 0.87 | 0.029 | 0.89 |
| L putamen (14) | 3931 [627] | 4599 [691] | 0.85 | 0.016 | 1 |
| R putamen (16) | 4001 [644] | 4738 [718] | 0.84 | 0.011 | 1.06 |
| L subthalamic nucleus (33) | 44.44 [8.22] | 54.61 [12.22] | 0.81 | 0.012 | 0.92 |
| R subthalamic nucleus (23) | 48.01 [9.06] | 53.81 [11.07] | 0.89 | 0.16 | 0.55 |
| Brainstem (20) | 26,895 [4139] | 31,254 [5289] | 0.86 | 0.031 | 0.88 |
| L cerebellum (67) | 56,396 [9507] | 75,397 [7275] | 0.75 | 1.5 × 10−6 | 2.36 |
| R cerebellum (76) | 57,909 [8996] | 76,808 [7348] | 0.75 | 1.2 × 10−6 | 2.39 |
| L lateral ventricle (3) | 19,405 [14461] | 4709 [1463] | 4.12 | 0.011 | 1.77 |
| R lateral ventricle (9) | 15,273 [8851] | 4120 [1667] | 3.71 | 0.0031 | 2.14 |
| 3rd ventricle (232) | 2596 [1989] | 1345 [349] | 1.93 | 0.079 | 1.08 |
| 4th ventricle (233) | 2394 [1109] | 2378 [1025] | 1.01 | 0.97 | 0.01 |
| Extracerebral CSF (255) | 364,823 [84889] | 420,249 [110651] | 0.87 | 0.18 | 0.54 |
Bold indicates statistically significant. Abbreviation; CS, CHARGE syndrome; NC, Normal control; SD, Standard deviation; L, left; R, right; GM, gray matter; WM, white matter; CSF, cerebrospinal fluid.