TABLE 3.
Differentially abundant taxa in vitamin A–supplemented group compared with placebo in male infants with birth weight above median1
Log2 fold change (SE) | P | Adjusted P | |
---|---|---|---|
Early infancy | |||
Phylum | |||
Proteobacteria | 0.451 (0.334) | 0.18 | 0.51 |
Family | |||
Moraxellaceae | −1.18 (0.365) | 0.0023 | 0.067 |
Corynebacteriaceae | 1.08 (0.415) | 0.011 | 0.16 |
Genus | |||
Acinetobacter | −1.10 (0.347) | 0.0024 | 0.11 |
Corynebacterium | 1.14 (0.413) | 0.0073 | 0.16 |
2 y | |||
Phylum | |||
Verrucomicrobia | −0.802 (0.605) | 0.178 | 0.42 |
Family | |||
Streptococcaceae | −1.21 (0.456) | 0.0092 | 0.16 |
Comamonadaceae | −0.76 (0.3) | 0.018 | 0.16 |
Actinomycetaceae | −0.593 (0.244) | 0.019 | 0.16 |
Eubacteriaceae | −0.343 (0.112) | 0.022 | 0.16 |
Gemellaceae | −0.437 (0.174) | 0.026 | 0.16 |
Genus | |||
Streptococcus | −1.34 (0.437) | 0.0029 | 0.16 |
Atopobium | −0.576 (0.197) | 0.0090 | 0.16 |
Megamonas | 1.79 (0.713) | 0.014 | 0.16 |
Gemella | −0.466 (0.176) | 0.018 | 0.16 |
Actinomyces | −0.592 (0.243) | 0.019 | 0.16 |
Comamonas | −0.766 (0.31) | 0.02 | 0.16 |
Pseudoramibacter_Eubacterium | −0.347 (0.114) | 0.02 | 0.16 |
Acidaminococcus | −0.541 (0.213) | 0.022 | 0.16 |
Sarcina | −0.651 (0.294) | 0.036 | 0.23 |
Dorea | −0.708 (0.352) | 0.047 | 0.28 |
1Differential taxa abundance at phylum, family, and genus levels was determined by fitZIG mixture modeling during early infancy (average of 6, 11, and 15 wk; n = 63) and at 2 y of age (n = 65). Taxa with a P value <0.05 or the lowest one were selected for this table. Early-infancy microbiota data were adjusted for type of delivery and breastfeeding status. Microbiota data at 2 y were additionally adjusted for age group at 2 y (older and younger). False discovery rate–adjusted P value (adjusted P) was calculated by the Benjamin-Hochberg method.