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. 2019 May 28;25(20):2450–2462. doi: 10.3748/wjg.v25.i20.2450

Figure 5.

Figure 5

Trimethylamine N-oxide modulates the expression of intestinal cholesterol transporters to inhibit cholesterol absorption in rats fed a high-fat high-cholesterol diet. A-D: Expression levels of cholesterol transporters in the duodenum; E-H: Expression levels of cholesterol transporters in the jejunum; I-L: Expression levels of cholesterol transporters in the ileum. The data are presented as the mean ± SE (n = 7-8). aP < 0.05, vs rats fed a chow diet; bP < 0.01, vs rats fed a chow diet; cP < 0.05, vs rats fed a high-fat high-cholesterol diet; dP < 0.01, vs rats fed a high-fat high-cholesterol diet. TMAO: Trimethylamine N-oxide; HFHC: High-fat high-cholesterol; NPC1L1: Niemann-Pick C1-Like 1; ABCA1: ATP-binding cassette transporter A1; ABCG: ATP-binding cassette subfamily G member.