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. 2019 May 23;10:362. doi: 10.3389/fpsyt.2019.00362

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Copyright © 2019 Shah, Sinharay, Matsuda, Schreiber-Stainthorp, Muthusamy, Lee, Wakim, Hirsch, Nath, Di Mascio and Hammoud

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sagittal and axial brain MRI images (A) as well as parametric maps of 11C-DASB BP_ND at baseline (B) and last time point (C) of SIV #4. Increased BP_ND can be detected visually at the last time point compared to baseline. Changes in BP_ND over the course of disease in all seven animals in the midbrain (D) and thalamus (E).