Figure 4.

The effect of combination therapy with SBP and GEM on the tumor microenvironment in LLC tumor model. (A) Representative micrographs of Glut1⁺, CAIX⁺, α-SMA⁺, and collagen⁺ signals of Saline, GEM 35 mg/kg, and SBP 32 mg/kg/GEM 35 mg/kg treated mice. (Scale bar: 50 μm). (B–E) Quantification of Glut1⁺, CAIX⁺, α-SMA⁺, and cleaved collagen⁺ signals of Saline, GEM 35 mg/kg and SBP 32 mg/kg/GEM 35 mg/kg treated mice (n = 5 for each group). ^*p < 0.05; ^**p < 0.01; ^***p < 0.001.