Figure 8.

Mean diastolic pressure (DBP) of rats dosed with pazopanib 30 mg/kg/day (n = 7) and vehicle (n = 4). (A) DBP and (B) change in DBP compared to baseline (ΔDBP) measured for 24 hours, (C) DBP and (D) ΔDBP measured during the morning (06:00‐12:00), (E) DBP and (F) ΔDBP measured during the evening (18:00‐23:45). Data displayed as mean ± SEM. *P < 0.05 comparing each time point to baseline; ⁺ P < 0.05 comparing vehicle vs pazopanib at the same time point and ^# P < 0.05 comparing area over or under the curve of vehicle vs pazopanib