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. 2019 May 24;10:1087. doi: 10.3389/fimmu.2019.01087

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Copyright © 2019 Matthijs, Auray, Jakob, García-Nicolás, Braun, Keller, Bruggman, Devriendt, Boyen, Guzman, Michiels, Haesebrouck, Collin, Barnier-Quer, Maes and Summerfield.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B cell and T/NK cell BTM induced by vaccines. The heat maps show the vaccine-dependent induction of BTM activity determined for D0 to D1 (D0 vs. D1), for D0 to D7 (D0 vs. D7), and for D1 to D7 (D1 vs. D7) changes in the modules. The values shown were calculated by −log(P-value)*1 for positively enriched BTM and as −log(P-value)* −1 for negatively enriched BTM. A cut-off of an FDR of q < 0.1 was employed. Red colors indicate BTM upregulation and blue downregulation. BTM, blood transcriptional modules.