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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Kidney Int. 2019 Apr;95(4):797–814. doi: 10.1016/j.kint.2018.11.042

Figure 8.

Figure 8.

Expression of NGAL and KIM1 as Marker of Unresolved Injury Following Cisplatin Administration

Protein isolated from control (n=3), 2 week-1 dose cisplatin (n=3), 4 week – 1 dose (n=3), and 4 week-2 dose cisplatin (n=3) mice. Western blot analysis of NGAL and KIM1 with GAPDH and beta-tubulin used as endogenous controls. Results are mean ± SE (n=3, compared with control, p < 0.05) from triplicate blotting. A) KIM1 protein expression significantly increased following the second dose of cisplatin, while NGAL protein expression increased following one and two doses of cisplatin. B) The increase in NGAL protein expression observed at two weeks following a single dose of cisplatin was resolved by four weeks. There was no observed increase in KIM-1 protein expression at two or four weeks after a single dose of cisplatin.